Mit nem érdemes enni, inni benzóelhagyásnál
A benzók fogyasztása miatt sérülnek a GABA receptorok, emiatt nem termelődik elegendő GABA az agyban, ami a szervezetet nyugtatja. A GABA (gamma-amino-vajsav) vegyületnek gátló hatása van: csökkenti a vérnyomást, a vércukor szintet, vagyis úgy általában fékez, nyugtat és kikapcsol. Az agy alvás közben nekiáll lebontani a GABA-t. A GABA glutamáttá bomlik le, ami egy éppen ellentétes hatású, serkentő neurotranszmitter. A receptorok sérülése miatt glutamát többlet alakul ki a szervezetben, ezért a benzók szedésének teljes abbahagyása után is sokan szenvednek még egy ideig - amíg a receptorok meg nem gyógyulnak - a glutamát többlet miatt elvonási tünetektől. Idegesebbek, rosszul alszanak, emésztési gondjaik vannak...stb... A GABA receptorok akkor tudnak gyógyulni, ha semmilyen olyan ételt nem eszünk vagy iszunk, melyek hatással vannak a működésükre. Sokan, akik ezt nem veszik tudomásul, és mégis fogyasztanak ilyen szereket, az elvonási tüneteik drasztikus erősödéséről számolnak be, valamint arról, hogy nem vagy nagyon nehezen gyógyulnak. Tehát NAGYON komoly állapotromlást okozhatnak!!! A legnagyobbat azoknál, akik lerakták teljsen a benzókat és már gyógyulófélben vannak....Éppen ezért aki gyorsan szeretne gyógyulni, vagy nem akar visszaesni, az jobb, ha tiltó listára teszi ezeket az ételeket és italokat, amíg meg nem gyógyul.
GABA receptorokra ható ételek, italok és egyéb szerek, melyek fogyasztását érdemes kerülni a teljes gyógyulásig. Ennek ideje egyénenként változó lehet, általában a gyógyszer teljes elhagyását követő 2 év, de egyénenként ez is változó lehet. Ezen lista a több ezer tagot számláló angol benzó csoportokban összeadódott tapasztalatok alapján jött létre.
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bármilyen benzó (nyugtató, antidepresszáns, altató)
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alkohol (2 évig javasolják nem fogyasztani) és alkohol tartalmú ételek, italok (Az etanol ugyanis GABAA- agonista, ami azt jelenti, hogy kis dózisban szorongásoldó, nyugtató, nagyobb mennyiségben narkotikus, izomlazító, altató hatású.)
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kávé
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antibiotikumok (benzó szedése során vagy korábbi benzót szedők között vannak, akiknél borzalmas ellenreakciót váltottak ki). Különösen a Fluorokinolonok családjába tartozók veszélyesek a benzót szedők számára, pl, ami levofloxacin nevű hatóanyagot tartalmaz, vagy a Ciprofloxacin…
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fájdalomcsillapítók
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táplálék-kiegészítők (vitaminok, ásványi anyagok)
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különös tekintettel: B vitamin, kálcium, D vitamin
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nyugtató hatású teák:
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levendulavirág,
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orbáncfű
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macskagyökér (valeriána)
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komlótoboz,
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citromfű
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galagonya
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hársfa
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kamilla
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nyugtató hatású gyógynövény tartalmú tabletták
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mesterséges édesítők (pl. aszpartám, szacharin…)
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ananász
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mandarin
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nátrium-glutamát (MSG = Monosodium Glutamate or Sodium Glutamate) Az egyik legáltalánosabban alkalmazott élelmiszer-adalékanyag, ízfokozóként ételízesítők alkotóeleme.
A benzó teljes elhagyása után az a tapasztalat az akut fázisba kerülők között, hogy a következő ételek fokozzák az elvonási tünetek súlyosságát a teljes gyógyulásig (A gyógyulást követően fogyaszthatóak, habár nem feltétlenül mind egészséges):
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cukor
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tejtermékek
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glutén
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gyors éttermi ételek (hamburgerek...stb... valószínűleg msg tartalom miatt)
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feldolgozott élelmiszerek (msg, glutén...stb...miatt)
Aki pedig még angolul szeretne az okokról bővebben olvasni, annak ajánlom a következő cikket:
**WHAT NOT TO TAKE WHILE ON BENZODIAZEPINES** -- by Shelby Register RN
PLEASE be very careful when giving or taking advice regarding supplements or natural "remedies" for benzodiazepine withdrawal and/or anxiety that comes along with the withdrawal process. A lot of people have gotten very bad reactions (set backs) to taking these things once they are off of benzodiazepines.This list is even more so for people off of benzodiazapines,not only on them. Once off of benzodiazapines,a lot of people find that things they take make their symptoms a lot worse. Particularly anything that works on the same Gaba Receptors that benzodiazapines work on.Taking anything that works on the damaged and fragile Gaba Receptors,tends to make them go even more haywire and then in turn brings on long waves of worse symptoms,or brings upon even more symptoms the person didn’t have prior to taking the certain thing
Many have the mistaken notion that all herbs and foods are safe to combine with medications because they are natural. However, everything you put in your mouth has the potential to interact since it travels the digestive system in similar ways to medications. Some drugs interfere with the body’s ability to absorb nutrients, and certain herbs and foods can speed up or slow down the action of a medication. Interaction symptoms can include headaches, flu-like symptoms, increased anxiety, insomnia, nausea and some can be life threatening. Know that an interaction can create unnecessary discomfort or pose a danger. This outlines herb, food and over-the-counter medications that may interact with Antidepressants, Benzodiazepines and Sleeping Pills.
Whether you are withdrawing from medications or not, it is critical to understand how many items can affect your prescriptions or heavily deplete the body. Below is just a sampling of items to avoid such as Passionflower, St. John’s Wort, 5-HTP, Caffeine, Barley Grass, Ginseng, Chinese Herbs and others. Some items such as artificial sweeteners should be avoided when possible, whereas specific herbs should be gradually tapered versus an abrupt discontinuation.
VITAMINS & HERBS:
While vitamins are generally safe, they are regularly consumed without appreciating that some have the potential to interact with medications. Herbs are plant-derived drugs, and while many may be beneficial, they can also pose a serious risk when combined with various prescription pills.
5HTP:
Combining 5-HTP with Antidepressants may cause an unsafe rise in Serotonin and lead to Serotonin Syndrome, a dangerous condition characterized by mental changes, hot flashes, rapidly fluctuating blood pressure and heart rate, and possibly coma. It is also not recommended to take with benzodiazepines.
Ashwagandha:
A study done at the Department of Pharmacology, University of Texas Health Science Center indicated that extracts of Ashwagandha produce GABA-like activity, which may account for the herb's anti-anxiety effects.11 GABA (Gamma Amino-butyric acid) is an inhibitory (calming) neurotransmitter in the brain. Its function is to decrease neuron activity and inhibit nerve cells from over firing.
Improves mood
Ashwagandha has traditionally been used to stabilize mood in patients with behavioral disturbances, and another study showed that it does indeed produce an anti-depressant and anti-anxiety effect in rodents comparable to the anti-depressant drug imipramine and anti-anxiety drug lorazepam (Ativan).12
Calcium:
Benzodiazepines and Sleeping Pills significantly inhibit the transport of calcium into the nerve cells in the brain, heart and throughout the body. The alteration of the calcium balance is what contributes to anxiety, fear, panic and muscle cramping, since Calcium modulates the effects on the GABA receptors. The GABA receptors are excited by Calcium supplements and even low dosage Calcium vitamins (not naturally occurring calcium in food items) can over-stimulate the brain neurons and increase anxiety, insomnia and fear.
California Poppy (ESCHSCHOLZIA CALIFORNICA):
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Sedative medications (Benzodiazepines) interacts with CALIFORNIA POPPY California poppy might cause sleepiness and drowsiness. Drugs that cause sleepiness and drowsiness are called sedatives. Taking California poppy along with sedative medications might cause too much sleepiness. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others.
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Sedative medications (CNS depressants) interacts with CALIFORNIA POPPY California poppy might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking California poppy along with sedative medications might cause too much sleepiness. Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.
Cats Claw:
Studies have revealed that Cat’s Claw binds to alpha-adrenoceptors, serotonin, dopamine and GABA receptors, and different phytochemical components have been demonstrated to depress motor activity and ameliorate memory disruption, indicating that Cat’s Claw is able to pass through the blood-brain barrier. By extrapolation, it would appear that Cat’s Claw has the potential to modulate pain responses within the Central Nervous System (CNS), in a similar fashion to antidepressant and anticonvulsant drugs used to modulate pain.
Chinese Herbs:
Chinese herbs can interact with many medications and either interfere or exaggerate their effects, which can lead to increased sedation and when combined with benzodiazepines, causing an unsafe lowering of blood pressure and suppression of the lungs. Some research indicates that many Chinese Herbs can interact with any medication that utilizes the P450 liver enzymes, which includes antidepressants, sleeping pills and benzodiazepines.
DHEA:
DHEA is an excitatory neuroactive steroid with stimulating effects. It enhances the activity of glutamate while reducing the activity of GABA. As a result, it may cause insomnia, anxiety, or mania and can greatly exacerbate the symptoms of benzodiazepine withdrawal.
"Exhilarin" (contains Holy Basil and Ashwagandha): (awaiting description)
Ginseng:
Ginseng can increase blood pressure, making it dangerous for anyone trying to control his or her blood pressure. Ginseng may over-stimulate the nervous system, resulting in insomnia. Therefore consuming caffeine with ginseng increases the risk of over-stimulation and gastrointestinal upset. Long-term use of ginseng may cause menstrual abnormalities and breast tenderness in some women. Ginseng is not recommended for pregnant or lactating women.
Gotu Kola (Centella Asiatica): (awating descriprion)
Grapefruit Seed Extract: (awating descriprion)
Holy Basil: (awating descriprion)
Hops: (awating descriprion)
Ibogaine:
Caution: First off, Iboga/Ibogaine is itself not completely safe and can have potentially fatal outcomes. Apart from that, Ibogaine therapies often suggest quitting cold turkey a day before taking ibogaine. (this applies to opioids) but Benzos nevertheless will have to be tapered off before. As soon as a low dose is reached or even better if one is completely off Benzos an Ibogaine Therapy can be considered to fully bring one back into life and vanish left overs of the addiction such as cravings, anxiety, depression. Slow Withdrawing prior to Ibogaine/Iboga treatment is a must.
Inositol:
Inositol is a naturally occurring element of glucose, though it is considered to be a member of the B vitamin family (B8). Serotonin selective reuptake inhibitors (SSRIs) have a similar therapeutic profile to Inositol – they both inhibit serotonin reuptake in the synaptic cleft. Inositol has an antidepressant effect and may involve the Serotonin receptors by enhancing or speeding up the response to SSRIs. The side effects are similar to SSRIs. This is also not recommended to take with benzodiazepines.
Kava:
Investigative studies suggest that Kava has addictive effects when combined with benzodiazepines, since it acts on the same GABA binding sites of the central nervous system. This can cause excess sedation, a lowering of blood pressure, physical depression, suppression of the lungs and cognitive impairment. https://www.researchgate.net/publication/14239497_Coma_from_the_Health_Food_Store_Interaction_between_Kava_and_Alprazolam
KAVIANCE It contains the following:
Vitamin B6 (as pyridoxine HCI and pyridoxal 5′-phosphate) Taurine and 4-amino-3-phenylbutyric acid HCI, which is a proprietary blend.
4-amino-3-phenylbutyric acid is PHENIBUT , which we cannot have as it's a weak, OTC benzo..
Please do not ingest this product.. Phenibut is a derivative of neurotransmitter GABA and chemically breaks down to beta-phenyl-gamma-aminobutyric acid. Phenibut can be addictive, cause withdrawal symptoms and tolerance in similar ways to a benzodiazepine. Symptoms of Phenibut withdrawal include insomnia, anxiety, sweaty hands and reduced appetite. Kratom:
This is the new "miracle" on the market for pain and anxiety. Many have reported adverse reactions when taken with benzodiazepines and it’s also illegal in some places
https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm584970.htm Lavender Essential oil:
Please note that lavender essential oil when ingested has an anxiolitic effect. When tapering it may be best to avoid ingestion http://www.sciencedirect.com/science/article/pii/S0378874113001840
Lemon Balm:
What it is most known for its ability to induce sleep and is considered a mild sedative. Lemon balm tea is used to calm colds and flu symptom. It is considered a carminative herb and is used to relieve spasm in the digestive tract. It is reduces dyspepsia associated with anxiety or depression, because of its sedative properties. The volatile oils appear to help the nervous system. Anxiety is associated with tension, and as such lemon balm is used for migraines that are associated with tension. Lemon balm and its chief component rosmarinic acid boost levels of GABA in the brain. This elevated GABA levels reduce the level of anxiety. Increasing brain GABA activity is the way which prescription anti-anxiety drugs work.
Licorice Root:
Licorice (Glycyrrhiza glabra, GG) is one of the most frequently used herbal medicines worldwide, and its various biological activities have been widely studied. GG is reported to have neurological properties such as antidepressant, anxiolytic, and anticonvulsant effects. However, its hypnotic effects and the mechanism of GG and its active compounds have not yet been demonstrated. In this study, GG ethanol extract (GGE) dose-dependently potentiated pentobarbital-induced sleep and increased the amount of non-rapid eye movement sleep in mice without decreasing delta activity. The hypnotic effect of GGE was completely inhibited by flumazenil, which is a well-known γ-aminobutyric acid type A-benzodiazepine (GABA(A)-BZD) receptor antagonist, similar to other GABA(A)-BZD receptor agonists (e.g., diazepam and zolpidem). The major flavonoid glabrol was isolated from the flavonoid-rich fraction of GGE; it inhibited [(3)H] flumazenil binding to the GABA(A)-BZD receptors in rat cerebral cortex membrane with a binding affinity (K(i)) of 1.63 μM. The molecular structure and pharmacophore model of glabrol and liquiritigenin indicate that the isoprenyl groups of glabrol may play a key role in binding to GABA(A)-BZD receptors. Glabrol increased sleep duration and decreased sleep latency in a dose-dependent manner (5, 10, 25, and 50mg/kg); its hypnotic effect was also blocked by flumazenil. The results imply that GGE and its flavonoid glabrol induce sleep via a positive allosteric modulation of GABA(A)-BZD receptors.
Magnolia:
"The bark contains magnolol and honokiol, two polyphenolic compounds that have been demonstrated as peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists and GABAA modulators." https://en.wikipedia.org/wiki/Magnolia_officinalis
Milk Thistle:
Milk thistle may interfere with many medications and increase them to dangerous levels because the same liver enzymes break down the herb. Milk thistle should not be combined with allergy medications, drugs for high cholesterol, anti-anxiety agents (alprazolam, diazepam, lorazepam, clonazepam, Temazepam), antiplatelet and anticoagulant drugs (blood thinners), anti-seizure medications, anti-psychotics, antidepressants, hormones and others.
N-Acetyl Cysteine (NAC):
N-acetyl cysteine (NAC) is an altered form of the amino acid cysteine, and assists the body in synthesizing Glutathione. The side effects reported include nausea, vomiting, headache, dry mouth, dizziness, blurred vision and abdominal pain. NAC increases zinc excretion, so supplementing with additional zinc and copper is recommended. Vitamin C must also be taken with NAC to prevent the cysteine from converting to cystine, which can form kidney or bladder stones. NAC is moderately effective at raising Glutathione levels, but dosing is limited due to the toxic side effects.
Passionflower:
Passionflower works by increasing levels of gamma-aminbutric acid (GABA) in the brain. Combining it with benzodiazepines, sleeping pills or antidepressants can cause excess sedation, physical depression including a suppression of respiration, an unsafe lowering of blood pressure, visual disturbances, pulmonary hypertension (high blood pressure in the arteries that supply the lungs), reduced plasma proteins and impaired cognitive function. Passionflower also may increase the amount of time blood needs to clot, so it could make the effects of blood-thinning medications stronger and increase the risk of bleeding. It is essential to gradually taper off passionflower rather than abruptly discontinue the herb, or the levels of other medications can change drastically.
Phenibut:
Phenibut is a derivative of neurotransmitter GABA and chemically breaks down to beta-phenyl-gamma-aminobutyric acid. Phenibut can be addictive, cause withdrawal symptoms and tolerance in similar ways to a benzodiazepine. Symptoms of Phenibut withdrawal include insomnia, anxiety, sweaty hands and reduced appetite.
In addition, Phenibut interacts with many medications including Benzodiazepines, MAO Inhibitors, Antidepressants, Stimulants and Sleeping Pills. Many supplements have Phenibut as an ingredient so please review labels carefully.
Picamilon: (awating descriprion)
Relora: (awating descriprion)
Skullcap (SCUTELLARIA LATERIFLORA): (awating descriprion)
St. John's Wort:
Mixing St. John’s Wort with Antidepressants can cause an overload of Serotonin, since the herb contains active principals that are comparable to medications for depression. But St. John’s Wort also affects other neurotransmitters increasing the amounts of dopamine, norepinephrine, l-glutamate and GABA. This makes it dangerous to combine with sleeping pills, benzodiazepines, amphetamines, asthma inhalants, decongestants, diet pills, narcotics, immunosuppressant drugs, and the amino acids tryptophan and tyrosine. Avoid the following substances when using St.-John's-wort: Amino acids tryptophan and tyrosine; amphetamines; asthma inhalants; beer, coffee, wine; chocolate, fava beans, salami, smoked or pickled foods, and yogurt; cold or hay fever medicines; diet pills; narcotics; nasal decongestants. They all contain chemicals that react adversely to hypericin, causing high blood pressure and nausea. It is essential to gradually taper off St. John’s Wort rather than abruptly discontinue the herb, or the levels of other medications can change drastically.
Valerian:
Because Valerian has the possibility of affecting the GABA receptors in much the same way as benzodiazepines, it is recommended to not combine with Alprazolam, Diazepam, Lorazepam, Clonazepam, Temazepam or Sleeping Pills. Valerian has been reported to cause excitability, headaches, stomach upset, uneasiness, unsteadiness, vertigo, low body temperature, and with chronic use, insomnia. A hangover effect has been reported with high doses and withdrawals may occur if you stop using Valerian suddenly. Symptoms could include cardiac complications, delirium and gastrointestinal discomfort.
Ziziphus:
FOODS & BEVERAGES:
The risk of a drug interaction isn't limited to herbal supplements and over-the-counter medications. Certain foods can interact with various prescription pills.
ALCOHOL & Alcohol contained in tinctures:
Alcohol is a drug that interacts with almost every medication, especially central nervous system agents and other drugs that affect the brain and nervous system. Alcohol interacts with most antidepressants, benzodiazepines and sleeping pills. The combination can cause fatigue, dizziness, slow reactions by increasing the concentration of medications. A small amount of beer, wine, or liquor can also increase the risk of stomach bleeding or liver damage when mixed with over-the-counter anti-inflammatory drugs and medications used to treat pain and fever. These include aspirin, ibuprofen and acetaminophen (Tylenol, Excedrin).
Barley Grass:
The fiber in barley may decrease the absorption of medications and prevent their full effects. Hordenine, a chemical in the root of developing barley, may stimulate the sympathetic nervous system and increase the heart rate and promote wakefulness.
Caffeine:
Caffeine increases anxiety and reduces the effectiveness of benzodiazepines. Caffeine is present in coffee, black tea, green tea, chocolate, some soft drinks and many over-the-counter medications. Caffeine is a stimulant and its effects can last up to 20 hours in the body. Some people will have disturbed sleep patterns even when their last cup of coffee was in the morning. So the sensible option is to avoid caffeine completely if taking a benzodiazepine, struggling with anxiety or insomnia.
Chamomile:
Chamomile is a member of the daisy family, and may intensify the effects of central nervous system medications such as benzodiazepines, narcotics, sleeping pills and antidepressants. This can cause excess sedation, a lowering of blood pressure, depression, suppression of the lungs and cognitive impairment. Chamomile can also increase the effects of anticoagulant medications (Warfarin, Coumadin, Aspirin), and its natural tannin content can interfere with iron absorption. "Compounds, other than apigenin, present in extracts of chamomile can also bind BDZ and GABA receptors in the brain and might be responsible for some sedative effect; however, many of these compounds are as yet unidentified."
Diet Drinks:
Diet Beverages contain artificial sweeteners including Aspartame, Splenda and Saccharin, which are all excitotoxins to the central nervous system. This can increase anxiety, panic, depression, insomnia, headaches and gastrointestinal issues. Ironically, it is well documented that excitotoxins can actually cause weight gain.
Grapefruit: & Clarithromycin: (two substances that work the same in the body)
Grapefruit affects more than 50 prescription medications since it inhibits an enzyme in the intestines that normally breaks down certain drugs, allowing more of a medication to enter the blood stream. The interaction symptoms can appear up to 3 days after eating or drinking grapefruit. This means you cannot drink grapefruit juice in the morning and take your medications late in the day. Grapefruit should be avoided with all Antidepressants, Benzodiazepines and Sleeping Pills. Grapefruit inhibits the cytochrome p40 enzyme, which allows the medication to build up in your system.
Grapefruit juice inhibits Cytochrome P450 (CY3PA specifically), which is found both in the liver and the wall of the small intestine. These enzymes metabolise benzodiazepines. The theory is, is that if the enzymes are inhibited then there will be greater bioavailability of the drug (for example, requiring lower doses to get the same effect). However it’s not quite so simple. This effect only comes into play if the parent drug is subject to extensive first pass metabolism. Drugs with high oral bioavailability (because of low first pass metabolism) are not affected by enzyme inhibition significantly. Obviously grapefruit juice does not have an effect if benzodiazepines are taken parenterally (IV or IM), because first pass metabolism is eliminated. SWIJ has seen it stated in various places on the net that it is only ruby grapefruit that has effect: Not so. Most of the studies were done with normal white grapefruit.
So, here we go. Benzos definitely potentiated by grapefruit juice: Triazolam (Halcion), Diazepam (Valium) and Midazolam (Versed) Benzos definitely NOT potentiated by grapefruit juice: Alprazolam (Xanax) Benzos theoretically potentiated by grapefruit juice, but effects probably not clinically significant (because of high oral bioavailability): Clonazepam (Klonopin), Lorazepam (Ativan), Chlordiazepoxide, Flurazepam (Dalmane), Temazepam (Restoril)
Pineapple:
Pineapple juice (pineapple in general) contains bromelain an enzyme that is supposed to help digesting proteins. Bromelain is known to increase the absorption of benzos. Experts believe bromelain may make sedative drugs stronger, including: Anti seizure medications, such as phenytoin (Dilantin) and valproic acid (Depakote) Barbiturates, Benzodiazepines, such as alprazolam (Xanax) and diazepam (Valium) Drugs to treat insomnia, such as zolpidem (Ambien), zaleplon (Sonata), eszopiclone (Lunesta), and ramelteon (Rozerem) Tricyclic antidepressants, such as amitriptyline (Elavil) Alcohol The same is true of herbs with a sedating effect, such as valerian, kava, and catnip.
Tangerine:
The name tangerine originated from Tangier, Morocco, the port where the first tangerines were shipped to Europe. Tangerines have been used in Korea to promote liver activity and stimulate the digestive system. But tangerine juice can interfere with the effectiveness of certain sleeping pills, antidepressants and anti-anxiety agents processed by liver enzymes known as P450. As a result, the levels of these medications may be decreased and their effects reduced.
Taurine: (awating descriprion)
Yakhult Fermented Milk:
“We recently have produced a new type of fermented milk containing GABA by using two kinds of starters—Lactobacillus casei strain Shirota, and Lactococcus lactis YIT 2027”
ARTIFICIAL SWEETENERS & FLAVOURINGS:
Many foods are laced with excitotoxins (toxins that affect the central nervous system) in the form of additives that cause brain cells to swell and die. Excitotoxins are included in beverages, artificial sweeteners and sauces. These compounds are often disguised as hydrolyzed vegetable protein, sodium caseinate, calcium caseinate, yeast extract, soy protein isolate, textured protein, and even natural seasoning and spices can be 12 to 40 percent MSG. Eliminating excitotoxins is essential to protect the brain, eyes, hypothalamus and the central nervous system. Even artificial sweeteners, sold as diet items, have actually been associated with weight gain.
Aspartame (NutraSweet, Equal):
Aspartame is an excitotoxin that was approved in 1981 and is 180 times sweeter than sugar. It can be found today in more than 7,000 commonly consumed foods, beverages and medications. All of Aspartame’s components are toxic to humans. Aspartame is 50% Phenylalanine, and 10% Methanol. Phenylalanine is an amino acid used by the brain. But anyone suffering from the genetic disorder phenylketonuria (PKU) cannot metabolize phenylalanine, and excess amounts can lead to a decrease of serotonin levels, and could cause emotional disorders and depression. Menthanol is also known as wood alcohol. Methanol breaks down in the body to produce formic acid and the deadly neurotoxin, formaldehyde, a known carcinogen that causes retinal damage and birth defects, interferes with DNA replication, and has been shown to cause a form of skin cancer in animals. Even low-level formaldehyde exposure can cause symptoms that include headaches, fatigue, chest tightness, dizziness, nausea, poor concentration and seizures. Aspartic acid is a neurotransmitter produced in the body to assist in the transfer of information from neuron to neuron. Consumption of aspartame creates an excess of synthetic aspartic acid that damages neurons by continuous over-stimulation. Another byproduct of metabolized aspartame is diketopiperazine (DKP). DKP has been associated with brain tumors and has been found to form in beverages that contain aspartame when stored above 86 degrees F. The most common side effects of aspartame are headaches/migraines, nausea, abdominal pain, fatigue, sleep problems, vision problems, depression, asthma and anxiety attacks. In the European Union, Aspartame is banned for use in any children’s products.
MSG (Monosodium Glutamate or Sodium Glutamate):
MSG or Monosodium Glutamate is also known as Protein Hydrolysate, Natural Flavor or Accent, and is used to enhance the taste of foods. MSG is addictive and can cause migraine headaches, anxiety, panic attacks, depression, short-term memory and cognitive impairment. MSG is an excitotoxin that causes more rapid cell death. MSG promotes a dangerous toxic reaction in many people and it is estimated that 30% of people get dizzy and disoriented after ingesting it. Research has also linked MSG to obesity since it damages the body’s ability to control weight. MSG is also known as Hydrolyzed Vegetable Protein, Accent, Aginomoto, Natural Meat Tenderizer, as many others. The list of side effects is extensive and includes cardiac variations (arrhythmia, atrial fibrillation, tachycardia, rapid heartbeat, palpitations, angina, extreme rise or drop in blood pressure), swelling, diarrhea, nausea/vomiting, stomach cramps, depression, mood swings, rage, migraine headaches, dizziness, mental confusion, anxiety, panic attacks, hyperactivity, behavioral changes, lethargy, insomnia, blurred vision and hives. Saccharin (Sweet-and-Low, Sugar Twin):
Saccharin was the first of the artificial sweeteners and is 300 times sweeter than sugar. It was discovered in 1879 by a chemist researching coal tar derivatives in the laboratory at Johns Hopkins University. He synthesized the reaction of anthranillic acid with nitrous acid, sulfur dioxide, chlorine and ammonia. Saccharin is absorbed rapidly in the digestive tract, cannot be metabolized, and therefore has been linked to concerns of bladder cancer. According to Andrew Laumbach, Ph.D., consumer safety officer in FDA's Office of Premarket Approval, "We know for certain that it (Saccharin) causes cancer in animals." Canada banned the use of saccharin, but it is allowed in the United States with a warning label stating saccharin may be a carcinogen. The common side effects are nausea, headaches, diarrhea, eczema, hives, itching, wheezing and excessive urination to name a few.
Sucralose (Splenda):
Sucralose is marketed as the sweetener Splenda and is about 600 times sweeter than sugar. Splenda is chlorinated sugar, or chlorocarbon. Some chlorinated molecules serve as the basis for pesticides (such as DDT), and store in the fatty tissues of the body. Although the manufacturer claims it passes through the body unabsorbed, the FDA’s “Final Rule” report stated the human body absorbs 11-27%. However, the Japanese Food Sanitation Council found that as much as 40% is absorbed. Sucralose was found to concentrate in the liver, kidney and gastrointestinal tract. Side effects include skin rashes/flushing, agitation, panic attacks, dizziness, numbness, diarrhea, muscle aches, headaches, intestinal cramping, bladder issues, stomach pain, chest pains, acne, bleeding, hair loss, heart palpitations, elevated blood pressure and many others.
OVER-THE-COUNTER (OTC) MEDICATIONS:
Whenever an over-the-counter item is taken with a prescription medication, there is a chance that there will be an interaction between them. The interaction may increase or decrease the effectiveness and/or the side effects and might also result in a new side effect that is not generally seen with the medications individually. The likelihood of drug interactions increases as the number of combinations increases. Most drug interactions are due to altered absorption in the intestine and can change the blood flow to the intestines, metabolism of the drug by the intestine, increased movement in the intestines resulting in diarrhea or constipation, alterations in the acidity of the stomach and a change in the bacteria of the gut region. The liver and kidney are where most drugs are eliminated and therefore are important sites of drug interactions. Drug interactions can be complex and unpredictable, so minimizing the risk is essential.
Antihistamines(Benadryl, Dimetapp, NyQuil, Alka-Seltzer Night-Time Cold, Thera Flu, ect.):
Over-the-counter (OTC) antihistamines are drugs that temporarily relieve a runny nose, or reduce sneezing, itching of the nose or throat, and itchy watery eyes. However, antihistamines increase the effect of benzodiazepines and sleeping pills and can cause cognitive deficits, dangerous drops in blood pressure, suppression of the lungs and extreme sedation. Antihistamines also alter the metabolism of many SSRIs, increasing blood levels of the Antidepressant and increasing their side effects. Combining antihistamines with hypertension medication may cause an increase in heart rate and blood pressure.
Nasal Decongestants (Afrin, Neosynephrine, Sudafed, ect.):
Most nasal decongestant sprays will cause increased adrenaline and norepinephrine, which can worsen anxiety and depression. Use of decongestants for longer than 3-5 days can damage the nasal tissue and lead to chronic congestion. Nasal decongestants may decrease the effectiveness of some blood pressure medications, and the most common side effects are stomach upset, trouble sleeping, dizziness, lightheadedness, headache, nervousness, fast heartbeat, loss of appetite and shaking.
Pain Relievers (Acetaminophen - Tylenol, Excedrin, ect. / Ibuprofen - Motrin, Advil, ect.):
Painkillers such as Acetaminophen and Ibuprofen are called analgesics, which numb pain. Both can have a profound effect on other medications, the absorption of nutrients and therefore to our general health. Acetaminophen, also known as Paracetamol, is widely used in over-the-counter pain reliever and fever reducer derived from coal tar and has been shown to reduce glutathione production (the body’s master antioxidant). Acetaminophen is metabolized primarily in the kidneys with a lesser amount traveling through the liver, where a toxic by-product called N-acetyl-p-benzoquioneimine (NAPQI) is produced in response to the acetaminophen, and is extremely harmful to the liver. The side effects of acetaminophen include nausea, vomiting, loss of appetite, diarrhea, sweating, irritability, abdominal pain (particularly near the liver), yellow eyes or skin, liver or kidney failure, heart problems and seizures. Ibuprofen reduces melatonin levels and may affect sleep if taken at bedtime. Other drugs that interfere with melatonin production are Valium, Xanax, diuretics, beta-blockers, calcium channel blockers, alcohol and caffeine. Ibuprofen may also exacerbate anxiety and depression by causing a disruption in the hormone system that participates in the contraction and relaxation of the muscles, blood vessels and modulates inflammation. Side effects include rash, riming of the ears, headaches, dizziness, abdominal pain, nausea, diarrhea, constipation, heartburn, bruising, tingling, numbness, nervousness, depression and insomnia.
Stomach Relievers (Maalox, Tums, Tagamet, Prilosec OTC, Pepcid, Zantac, ect.):
Over-the-Counter medications that reduce the production of stomach acid can upset the natural balance of healthy bacteria required for good health, and allow unhealthy bacteria to proliferate. Proton-pump inhibitors block stomach acid production AND increase the risk of a common infectious form of diarrhea. Taking a heartburn medication (Nexium, Losec) significantly increase the risk of diarrhea from the Clostridium difficile bacteria. Frequently prescribed anti-heartburn drugs called H2 antagonists (Zantac, Prevacid) double the risk of the bacterial diarrhea. PPIs and H2 antagonists reduce gastric acid, allowing for bacteria to multiply in the digestive system. While antibiotics formerly blamed for outbreaks of the illness have declined in use, the acid-blocking drugs have become steadily more popular to treat ulcers and conditions such as gastric reflux disease. Additionally, stomach medications can slow the absorption of benzodiazepines and sleeping pills and lead to increased anxiety and insomnia. Antacids taken with antibiotics, heart and blood pressure or thyroid medications can decrease their absorption up to 90 percent, and may pose a concern with certain antidepressants. Antacids also bind to nutrients and prevent proper absorption.
Medications for GERD and acid reflux can potentiate the benzodiazepines in your system. The proton pump inhibitors (PPIs) are the most effective antisecretory agents used to treat acid-related disorders. As such, they are frequently prescribed for patients who are concurrently using other medications. PPIs may interact with other drugs through numerous mechanisms. The most important include competitive inhibition of hepatic cytochrome P (CYP) 450 enzymes involved in drug metabolism, and alteration of the absorption of other drugs via changes in gastric pH levels. Poor metabolizers, who lack CYP2C19, may be particularly predisposed to drug interactions. Although the potential for drug interactions is high, few clinically significant interactions have been reported for the PPIs. Nevertheless, caution is indicated when certain drugs are co-prescribed with these agents. The incidence of clinically significant drug interactions increases proportionately with the number of drugs taken and with the age of the patient. The drug interaction with the greatest clinical importance is the reduction in benzodiazepine clearance by omeprazole.
--Division of Gastroenterology, Stanford University School of Medicine, CA, USA. MAY 13th, 2001
OTHER DRUGS:
GHB / GBL: (awating descriprion)
Nefiracetam: (awating descriprion)
Progesterone: Progesterone is cross tolerant to benzos.
The metabolites of progesterone, allopregnolone and pregnolone, act on the GABA receptors the same way that benzos do. It can have the same effect as a benzo dosage increase. Here are a few articles that explain how they act in the same way as benzos on the GABAa receptor:
The steroids most studied are allopregnanolone (ALLO), tetrahydrodesoxycorticosterone (THDOC), pregnenolone sulfate (PS) dihydroepiandrosteronesulfate (DHEAS), and estradiol (E2). ALLO and THDOC are called gamma-aminobutyric acid (GABA) steroids as they are positive modulators of the GABAa receptor in a similar way as benzodiazepines, barbiturates, and alcohol.
The positive modulators of the GABAa receptor include allopregnanolone and pregnanolone, both neuroactive metabolites of progesterone, as well as benzodiazepines, barbiturates, and alcohol.
Previous studies have determined that allopregnanolone enhances the activity of GABA, the main inhibitory neurotransmitter in the central nervous system, at its receptors throughout the brain. This mechanism, Toufexis said, likely accounts for progesterone's blunting effect on the brain's stress system.
Progesterone is categorized as being cross tolerant to benzos because it modulates the GABAa receptor in the same manner.
Neuroactive steroids, e.g., progesterone and its active metabolite allopregnanolone, are positive modulators of the GABAa receptor and are cross tolerant with benzodiazepines. The active metabolite of progesterone has been found to enhance the binding of benzodiazepines to the benzodiazepine binding sites on the GABAa receptor. The cross-tolerance between GABAa receptor positive modulators occurs because of the similar mechanism of action and the subunit changes that occur from chronic use from one or more of these compounds in expressed receptor isoforms. Abrupt withdrawal from any of these compounds, e.g., barbiturates, benzodiazepines, alcohol, corticosteroids, neuroactive steroids, and nonbenzodiazepines, precipitate similar withdrawal effects characterized by central nervous system hyper-excitability, resulting in symptoms such as increased seizure susceptibility and anxiety.
Another thing it has in common with benzos is its effects on the corticotropin-releasing factor (CRF), also called the corticotropin-releasing hormone (CRH).
The scientists found evidence that the progesterone metabolite allopregnanolone reduces the brain's response to corticotropin-releasing factor (CRF), a peptide hormone that plays an important role in the stress response in animals.
Plus it has its own withdrawal syndrome.
ANTIBIOTICS:
DO NOT TAKE ANY ANTIBIOTIC THAT IS IN THE FLOUROQUINOLONE FAMILY. These usually have "flox" in the name-levafloxacin (Levaquin), ciprofloxacin (Cipro), ect. This family of antibiotics cause a SEVERE adverse reaction when taken with benzodiazepines.
Added information and noted contraindications:
Activated charcoal:
Activated charcoal can cause an acute withdrawal reaction when used while on benzodiazepines. If your question is not answered in this list feel free to ask in group and double check on drugs.com for interaction.
Avoid DETOXES:
Detoxification can strip the active ingredients of medications from your body and blood stream putting you at risk for a cold turkey reaction that can be difficult to pinpoint since you may be still taking your medication daily. Please be mindful that detox will rid the body of good nutrients, medications, and in some cases even your intestinal flora and yeasts that can cause major side effects to even someone who is very healthy.
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